Nanosuspension a novel approaches in drug delivery system. Formulation development studies were conducted in this work so as to aid in. Medical university chennai 600032 in partial fulfillment of the requirements for the award of degree of master of pharmacy in pharmaceutics su bmitted by reg. Development of nanosuspension formulation for oral deli very of quercetin state of drug in ns was estimated by an xray diffractome ter dmax rb, rigaku co. Formulation and evaluation of pitavastatin nanosuspension a dissertation submitted to the tamilnadu dr. Formulation and development of stable metaxalone nanosuspension using 32 factorial design nanosuspensions are the dispersions of nanosized particles in a suitable vehicle prepared using surfactants or solubilizers to aid in nanosize distribution. Media milling, in vitro dissolution, solubility enhancement, nanoparticles, formulation optimization. The studies indicated poten tial of these formulations as novel. Development, characterization and evaluation of tinidazole nanosuspension for treatment of amoebiasis pawar rn, chavan sn and menon md department of pharmaceutics, bombay college of pharmacy, mumbai, maharashtra, india abstract amoebiasis is an infectious disease of gastrointestinal tract caused by the protozoan, entamoeba histolytica. Particle size was found to be influenced by the type of stabilizer, concentrations of stabilizer, and homogenizer speed. Formulation and optimization of nanosuspensions for enhancing.
Stability studies proved that nanosuspensions were more stable with no significant changes in particle size distribution. Oral bioavailability of this tablet formulation is only 26%. After reconstitution of the lyophilized nanosuspension formulation with sterile water for injection, the drug was then further diluted with 0. The developed mucoadhesive nanosuspensions exhibited satisfactory physical stability. In vitro plasma compatibility study of a nanosuspension. As shown in table 3 the drug content was found to be 99.
The nanosuspension drug delivery system dds was firstly reported in 1994 muller et al. Subsequent trials can be completed with the same technology through the preparation of larger volumes of nanosuspension sample material. The optimized nanosuspension nclh5 prepared using combination of tween 80 and poloxamer 188 as stabilizer, showed particle size of 35. Formulation development and evaluation of metronidazole magnetic nanosuspension as a magnetictargeted and polymericcontrolled drug delivery system. Maintaining the stability in solution as well as in solid state. Nanosuspensionbased formulation development for the first. The invitro plasma compatibility of the formulation was evaluated under conditions that mimic intravenous injection. By enabling closed vessel, contamination free wet milling in a scalable manner, earlystage compounds can be dosed and evaluated, without extensive formulation development, with a very minimal amount of material.
Formulation of nanosuspension and selection of process parameters nanosuspension was prepared by precipitationultra sonication technique6,71 the precipitation step was carried out by the addition of saturated drug solution in antisolvent solution water and surfactant mixture with stirring for predecided time interval subsequently the. Formulation and optimization of nanosuspensions for enhancing simvastatin dissolution using central. In the course of the development of a nanosuspension formulation, one first screens various surfactant packages to. Design development of cefdinir niosomes for oral delivery. Kaempferia parviflora nanosuspension formulation for. Its marketed product benicar is available in the form of tablet. Formulation and optimization of nanosuspensions for enhancing simvastatin dissolution using central composite design vikram m.
Formulation and evaluation of cefixime nanosuspension for the. Osmolarity intravenous dosage form should be isoosmolar with the blood 250350mosmoll so the optimized nanosuspension formulation was checked for osmolarity and results revealed. Production and stabilization of nanosuspensions of poorly soluble. Pdf with the aim to enhance dissolution rate and oral bioavailability of quercetin, a poorly watersoluble drug, quercetin loaded. Patel pharmacy college, linch, mehsana, gujarat, india 2nootan pharmacy college, visnagar, gujarat, india. Formulation as nanosuspension is an attractive and promising alternative to solve these problems. Quantitative estimation of lercanidipine hcl in bulk material as well as from nanosuspension formulations via a developed reverse phase hplc method. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Enhanced antihypertensive activity of candesartan cilexetil. Emerging role of nanosuspensions in drug delivery systems.
Identification of critical process parameters and its. In the course of the development of a nanosuspension formulation, one first screens various surfactant packages to achieve the desired. Formulation, optimization and evaluation of oral nanosuspension tablets of nebivolol hydrochloride for enhancement of dissoluton rate kiran thadkala 1, chintha sailu 2 and jithan aukunuru 1, 1mother teresa college of pharmacy, osmania university, ghatkesar, hyderabad, telangana, india. Formulation and evaluation of nanosuspension formulation for drug delivery of simvastatin 2651 by continuous stirring. Development and validation of reversed phase highperformance liquid chromatography method for estimation of lercanidipine hcl in pure form and from nanosuspension formulation abstract aim. Formulation optimization and evaluation of cefdinir nanosuspension. Cefdinir by preparation of its nanosuspension by solvent evaporation technique. In this study, the qtpp was defined to produce a resveratrol nanosuspension with high stability and suitable oral bioavailability. Formulation, optimization and characterization of simvastatin. A surprisingly large proportion of new drug candidates emerging from drug discovery programs are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. Pdf development of nanosuspension formulation for oral.
Variability of fedfasted state bioavailability with nanosuspension formulation can. Preparation and evaluation of nanosuspension of nifedipine. The purpose of this study is to optimize the preparation of nanosuspensions of kp extract for enhancing intestinal absorption using antisolvent precipitation technique which is an accessible. This development included a literature search for suitable stabilizers that are accepted for iv application as well as a small scale screening of various formulations and evaluation of the bioburden of the formulation.
The present work was aimed at the formulation and evaluation of nanosuspension of nifedipine, a poorly water soluble antihypertensive drug. Nanosuspensions accelerate drug substance dissolution rates by increasing surface area and reducing particle size. Nclh5 was chosen optimized formulation and further evaluated for other parameters after lyophilization. Pdf the present study is aimed to formulate and evaluate. Formulation and evaluation of acyclovir nanosuspension for. Patel building of pharmacy, pharmacy department, faculty of technology and. Formulation and characterization of itraconazole oral nanosuspension. Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. Development and characterization of nanosuspensions of. Nanosuspension is a colloidal dispersion of submicron drug particles. Introduction poor solubility of a drug is a major concern for the development of new dosage form because about 10% of the present drugs, 40% of the drugs in the pipeline and 60% of drugs coming directly from synthesis have a. Pdf development of pik75 nanosuspension formulation with. Kaempferia parviflora kp is an herbal medicine for enhancement of physical fitness and male sexual function improvement with low oral absorption of the main active compounds, methoxyflavones.
Preparation and characterisation of nevirapine oral. The great challenge for the pharmaceutical development is to create new formulation approaches and drugdelivery systems to overcome solubility problems of these drug candidates which are also often associated with poor oral bioavailability 1,3,4. The key to nanosuspension development is the identification of a suitable stabiliser system, such that crystal growth and agglomeration effects are suppressed during the lifetime of the formulation. Formulation development and optimization of nanosuspension of simvastatin for improved solubility by nanomilling satya sankar sahoo1,2, chandu babu rao2, ashis kumar mehta1 introduction approximately 40% of drugs in the drug discovery pipeline that show promising activity are poorly soluble in water 12. Preparation and characterization of nanosuspension of.
Development and evaluation of some novel nanosuspension is my own work and that, to the best of my knowledge and belief, it contains no material previously published or written by another person nor material which has been accepted for the award of. Formulation, characterization and pharmacodynamic study chetan detroja, sandip chavhan, and krutika sawant drug delivery laboratory, centre of relevance and excellence in ndds, g. Formulation, optimization and characterization of candesartan. In addition, the nanosuspension is processed to a solid formulation by freeze drying. Nanosuspension consists of the pure poorly watersoluble drug without any matrix material suspended in dispersion. Development and validation of reversed phase highperformance.
Preparation of nanocrystals is quite easy, but the stability and selection of stabilizer in optimum concentration are critical in formulation development. Nanosuspensionbased formulation development for the firstinclass plk2 inhibitor, gbo006, toward indenabling studies. Development of a nanosuspension for iv administration. Pdf design, formulation and evaluation of nanosuspension for. These techniques are helpful for an efficient comparison among formulations and for the development of an optimized product. Nanosuspension, saturation solubility, solubility enhancement. Formulation, optimization and characterization of simvastatin nanosuspension prepared by nanoprecipitation technique vikram m. Formulation considerations for the nanosuspension formulation. Identification of critical process parameters and its interplay with nanosuspension formulation prepared by top down media milling technology a qbd perspective. Arshad ahmed khan department of pharmaceutics, raghavendra institute of pharmaceutical education and research, anantapuramu515721, andhra pradesh, india. Pdf development of pik75 nanosuspension formulation.
Therapeutics applications of nanosuspension in topical. Formulation development and optimization of nanosuspension. Nano suspension is one of the techniques that can improve the dissolution of poorly soluble drug. Formulation and evaluation of cefixime nanosuspension for the enhancement of oral bioavailability by solventantisolvent method and its suitable method development vinayak shivamurthi mastiholimath 1, bhagat ankita rajendra1, vinodkumar shirshalappa mannur, panchaxari mallappa dandagi2, anand panchaxari gadad2, pukar khanal3. Formulation development and optimization of nitrendipine. The use of drug nanosuspension is an universal formulation approach to increase the therapeutic performance of these drugs in any route of administration. Formulation and characterization of itraconazole oral. Enhanced antihypertensive activity of candesartan cilexetil nanosuspension.
Development of pik75 nanosuspension formulation with enhanced delivery efficiency and cytotoxicity for targeted anticancer therapy. Methyl cellulose as promising stabilizer nehal daebis 1, ossama y abdallah2, magda elmassik, and hamdy abdelkader3 1department of pharmaceutics, faculty of pharmacy and drug manufacturing, pharos university, alexandria, egypt. The felodipine nanosuspension formulation f5 and f6 released 100 % of drug in 9 h only, where as nanosuspension formulation f1, f2, f4 and f7 released all drug in 10 h and nanosuspension formulations f3 and f8 released complete drug in 12 h fig. For enhancing the efficiency of nanosuspension development it is crucial to. Patel pharmacy college, linch, mehsana, gujarat, india 2nootan pharmacy college, visnagar384315, gujarat, india. Development of solidself micron emulsifying drug delivery systems 2053 research paper formulation development and optimization of nitrendipine nanosuspension with improved pharmacokinetic characteristics anand shah1, vipul patel2 and sunny shah3. Development of a resveratrol nanosuspension using the. Formulation and optimization of nanosuspensions for. Drug nanocrystals in the commercial pharmaceutical development process.
Formulation development and evaluation of acyclovir orally disintegrating tablets manisha karpe, nikhil mali and vilasrao kadam abstract orally disintegrating systems have an edge amongst the oral drug delivery systems due to the highest component of compliance they enjoy in patients especially the geriatrics and pediatrics. Nanosuspension is the fine dispersion of uniformsized solid particles in an aqueous vehicle. In order to produce small particle size, often a highspeed homogenization or. Formulation development and evaluation of acyclovir orally. Introduction the formulation of poorly watersoluble drugs has always been a challenging problem faced by pharmaceutical. Formulation development and optimization of nanosuspension of. Lyophilized nanosuspension formulation intended for intravenous administration has been developed. Pdf formulation development and evaluation of metronidazole.
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